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CTMS Module 6 of 29

Risk & Issue Management

Risk register with mitigation tracking and issue resolution workflows.

Module Overview

The Risk & Issue Management module maintains a comprehensive risk register with probability-impact scoring, mitigation plans, and residual risk assessment. Issues are tracked through structured resolution workflows with assignment, root cause analysis, CAPA linkage, and closure verification.

Key Features

Risk register with probability-impact scoring matrix
Mitigation plan tracking with action items and deadlines
Issue logging with severity, assignment, and resolution workflow
Root cause analysis documentation
CAPA linkage for quality-related issues
Risk dashboard with heat map visualization

Workflow & Interface

Explore the module's workflow through interactive interface mockups showing each step of the process.

1

Risk Register & Heat Map

Maintain a structured risk register with probability-impact scoring. Visual heat map identifies high-priority risks.

medifirm-ctms — module view
Risk IDDescriptionProbabilityImpactScoreStatus
R-001Slow enrollment at EU sitesHighMedium12
Mitigating
R-002Protocol amendment delayMediumHigh12
Monitoring
R-003CRO resource constraintsMediumMedium9
Accepted
R-004Data quality at Site DLowHigh8
Mitigating
R-005Regulatory query responseLowMedium6Closed
2

Issue Resolution Workflow

Track issues through structured resolution workflow from identification to closure with root cause analysis.

medifirm-ctms — module view

ISS-001

Protocol deviation at Site B

Investigating

ISS-002

Data entry backlog at Site D

In Progress

ISS-003

Missed visit — Subject 012

Root Cause

ISS-004

Lab sample shipping delay

CAPA Linked

ISS-005

CRF completion error

Resolved
3

Risk Dashboard

Overview of risk profile across the study with trend analysis and mitigation progress tracking.

medifirm-ctms — module view

Total Risks

24

12 active, 12 closed

High Priority

4

Requires action

Open Issues

7

3 escalated

CAPA Linked

3

Quality integration

Module Connections

How Risk & Issue Management integrates with other CTMS modules in the platform.

BidirectionalQMS & CAPA

Quality issues linked to CAPA workflows

View Module
Sends toCentral Monitoring

Risks trigger targeted monitoring activities

View Module
BidirectionalRBQM Plan

Risk register feeds RBQM strategy

View Module
BidirectionalStudy Management

Study-level risk profile maintained

View Module
BidirectionalAI Agent Recommendations

AI analyzes risk patterns for recommendations

View Module